Total Synthesis of -Dactylol

DIASTEREOSELECTIVE INTRAMOLECULAR 4+3 CYCLOADDITION AND AN ENANTIOSELECTIVE TOTAL SYNTHESIS OF (+)-DACTYLOL... 

Eiirstner, A. and Langemann, K. (1996) A concise total synthesis of dactylol via ring closing metathesis. /. Otg, Chem, 61, 8746-8749. 

A number of nonbiogenetic total syntheses of dactylol in both racemic and optically pure forms have appeared in literature. The first example is the work reported in 1986 by Gadwood and eo-workers. (Scheme 3). This synthesis began with the eonversion of enone 5 into cyclobutanone 6. The cyclooctanoid framework was constructed using an oxy-Cope... 

Paquette, L.A. and Ham, W.H. (1987) Total synthesis of the marine sesquiterpenes dactylol and africanol de novo construction of a cydooctanoid natural product from cycloheptane precursors. J. Am. Chem. Soc., 109, 3025-3036. 

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