Tosic anhydride

Aminopyridine Tosic anhydride is used in activating pyridine-A -oxide and homologues for attack by t-butylamine. The resulting 2-t-butylaminopyridine is dealkylated by CF3COOH. 

In much the same vein, acetylation of optically active cf-norgestrel by means of acetic anhydride and tosic acid gives the 17-acetate (72). Reaction with hydroxylamine hydrochloride in pyridine affords the orally active progestin dexnorgestrel acetime (73). ... 

The scheme required to prepare the potent tri-fluoro corticoid cormethasone acetate (292) illustrates the synthetic complexities involved in some of this work. Sequential acetylation of the pregnenolone derivative 278 with first acetic anhydride in pyridine and then acetic anhydride in the presence of tosic acid affords diacetate 279. Reaction of that intermediate with nitrosyl fluoride results initially in addition of the reagent to the 5,6-olefin moiety to afford the fluoro oxime reaction with a second mole of reagent at nitrogen gives the nitroimine derivative 280 passage over alumina serves to hydrolyze the imine function to the corresponding 6-ketone (281). 

Tolyl Epoxypropyl Ether Tolyl Glycidyl Ether Tosic Acid Toxaphene Toxichlor Toxilic Acid Toxilic Anhydride Transformer Oil... 

---