Cormethasone acetate

The scheme required to prepare the potent tri-fluoro corticoid cormethasone acetate (292) illustrates the synthetic complexities involved in some of this work. Sequential acetylation of the pregnenolone derivative 278 with first acetic anhydride in pyridine and then acetic anhydride in the presence of tosic acid affords diacetate 279. Reaction of that intermediate with nitrosyl fluoride results initially in addition of the reagent to the 5,6-olefin moiety to afford the fluoro oxime reaction with a second mole of reagent at nitrogen gives the nitroimine derivative 280 passage over alumina serves to hydrolyze the imine function to the corresponding 6-ketone (281). 

Amcinafal Amcinafide Cormethasone Acetate Cortivazol Desonide Di fluprednate Drocinonide Endrysone... 

Corey lactol, 4 Cormethasone acetate, 194 Cormethasone acetate, 196 Cortisone, 176, 179 Cortivazol, 191 Cotinine, 235 Curare, 162 Cgclacillin, 439 Cgclazocine, 327 Cyclic adenosine monophosphate, see CAMP Cgclobendazole, 353 Cyclopropanation, 32, 166, 168, 174. 223, 297 Cgheptamide, 222 Cypenamine, 7 Cyprazepam, 402 Cyprolidol, 31 Cyproquinate, 368 Cyproterone acetate, 166 Cyproximide, 293... 

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