Topological rule stereochemistry

Seebach and Golinski advanced a topological rule to account for the stereochemistry of enamine Michael additions along with many other... 

In addition to starting material selection, CAESA carries out an analysis of the structural features of a molecule that give rise to synthetic difficulty or complexity using a rule-based expert system. This system identifies and quantifies the molecular complexity that results from the topology, the stereochemistry. 

Both the Woodward-Hoffmann and Fukui frontier orbital analyses lead to the same results as the general Woodward-Hoffmann rule, and both therefore correctly predict the topology of pericyclic processes. Although there are serious objections to this approach, nevertheless it is a very useful mnemonic device for illustrating the stereochemistry of the orbital interactions that occur in pericyclic changes as predicted by the general Woodward-Hoffmann rule. 

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