Topological encapsulation of guest molecules

The possibilities for encapsulating guest molecules in dendritic hosts were first proposed by Maciejewski in 1982 [143], In 1990, Tomalia presented evidence for unimolecular encapsulation of guest molecules in dendrimers and pointed out that it was one of the possible future research areas in dendrimer chemistry [164], 

Further investigation of this host-guest system showed not only that different guests could be incorporated in one host, but also that guest molecules of different size could be liberated in a shape selective fashion [168, 169]. 

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