Topoisomerase Il-mediated

Adlakha RC, Ashorn CL, Chan D, Zwelling LA. Modulation of 4 -(9-acridinyl-amino)methanesulfon-m-anisidide-induced, topoisomerase Il-mediated DNA cleavage by gossypol. Cancer Res 1989 49 2052-2058. 

Mittra B, Saha H, Chowdhury AR et al. LuteoUn, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase Il-mediated kinetoplast DNA cleavage leading to apoptosis. Mol Med 2000 6 527-541. 

The different mechanisms of MDR observed in tumor celk can be classified into (a) P-glycoprotein-mediated (165,197,198) (b) multidrug resistance protein (MRP)-mediated (199,2(X)) (c) lung resistance protein (LRP)-mediatcd (201) and (iv) topoisomerase Il-mediated (at-ME)R) (143,162,165,167,196). By fw. the most important resistance mechanism is that mediated by PI 70, a member of the transmembrane. mul-tidn resistance exporter protein family (165,197,198). 

Marshall, K.M., Matsumoto, S.S., Holden, J.A., Conception, G.P., Tasdemir, D., Ireland, C.M., and Barrows, L.R. (2003) The anti-neoplastic and novel topoisomerase Il-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine. Biochem. Pharmacol, 66, 447-458. 

Holm B, Jensen PB, Sehested M, Hansen HH. In vivo inhibition of etoposide-mediated apoptosis, toxicity, and antitumor effect by the topoisomerase Il-uncoupling anthtacydine adarubicin. Cancer Chemother Pharmacol 1994 34 503-508. 

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