Topitracin - Bacitracin

Bacitracin. Altracin Ayfivin Fortracin Penitra-cin Topitracin Zutracin. Antibiotic polypeptide complex produced by Bacillus subfilis and licheniformis Johnson et al, Science 102, 376 (1945) Anker et at. J. Bacterial 55, 249 (1948). Commercial bacitracin is a mixture of at least nine bacitracins. Purification of bacitracin by carrier displacement method Porath, Acta Chem. Stand. 6, 1237 (1952). Purification with ion exchange resin Chaiet, Cochrane, U.S, pat. 2,915,432 (1959 to Merck Co.). Production Johnson, Meleney, U.S. pat- 2,498,165 (1950 to the U.S. Secy, of War) Freaney, Allen, U.S, pat. 2,828,246 (1958 to Commercial Solvents). Solubilities Weiss et al, Antibiot. Che-mother. 7, 374 (1957). Preliminary structure studies Haus-mann et at, J. Am. Chem. Soc. 77, 723 (1955) Lockhart et of, Biochem. J. 61, 534 (1955) St off el, Craig, J. Am. Chem. Soc. 83, 145 (1961), Structure of bacitracin A Ressler,... 

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