TOPICAL electrophoretic mobility

It is apparent from the above sections that the understanding of electrophoretic mobility involves both the phenomena of fluid flow as discussed in Chapter 4 and the double-layer potential as discussed in Chapter 11. In both places we see that theoretical results are dependent on the geometry chosen to describe the boundary conditions of the system under consideration. This continues to be true in discussing electrophoresis, for which these two topics are combined. As was the case in Chapters 4 and 11, solutions to the various differential equations that arise are possible only for rather simple geometries, of which the sphere is preeminent. 

Conceptually. CE enantioseparations are mainly applied to charged SAs. Micellar electrokinetic chromatography (MEKC) (introduced by Terabe et al. in 1984 488 ), in contrast, permits the separation of electrically neutral compounds. In enantiomer separation by MEKC. ionic pseudo-stationary phases, such as chiral micelles composed of chiral SO moieties, which migrate according to their electrophoretic mobility, may interact stereoselectively with the solutes to be separated. MEKC with synthetic (e.g. A-dodecoxycarbonylvalines, commercialized as SDVal by Waters) 1489.490) or naturally occurring chiral surfactants (e.g. bile salts) 1491-494). and cyclodextrin-moditied MEKC (most often SDS/CD combinations) 1495-498) are the mo.st widely used selector systems in MEKC. The topic of MEKC enantioseparation has been reviewed by Nishi )499). 

II, we describe recent experimental and theoretical advances in understanding electrophoretic mobility of DNA in agarose gels [7,8] as well as the anomalous migration of intrinsically curved DNA sequences [9-19], and protein-DNA complexes in polyacrylamide gel [20-28,3,4], In the second part, Sec. Ill, we briefly review two topics involving the polyelectrolyte characteristics of DNA [1] Coulombic end effects and (2) the connection between Poisson-Boltzmann and counterion condensation approaches. 

So far most efforts have been devoted to the determination of the drag force exerted by the surrounding fluid on a translating aggregate. The literature that has been devoted to this topic is already quite impressive and has been recently summarized by Coelho et al. [38]. The purpose of this section is to extend the analysis to electrophoretic mobility, i.e., to isolated particles to which an electric field is applied. As previously stated, the same formalism as for porous media can be applied to suspensions. 

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