Tomatine liposomes

Steel CC, Drysdale RB (1988) Electrolyte leakage from plant and fungal tissues and dismption of liposome membranes by a-tomatine. Phytochemistry 27 1025... 

In vitro studies by Roddick and Drysdale on the effect of tomatine on the leakage of peroxidases from liposomes also support the idea that tomatine binds membrane sterols. They detected a significant disruption of the liposome by tomatine, only if the membranes contained sterol and additionally this destabilization was pH-dependent [27]. Later it was demonstrated that liposome membranes containing sterols but lacking 30-hydroxy sterol were resistant to tomatine [28]. 

Amin, M., Kurosaki, F. andNishi, A. (1998) Carrot phytoalexin alters the membrane permeability of Candida albicans and multilamellar liposomes. J. Gen. Microbiol. 134, 241-246 Apel, K. and Hirt, H. (2004) Reactive oxygen species metabolism, oxidative stress and signal transduction. Ann. Rev. Plant Biol. 55, 373-399 Ameson, P.A. and Durbin, R.D. (1968) The sensitivity of fungi to a-tomatine. Phytopathology 58,536-537... 

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