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Tolmetin glucuronide

A Ding, P Zia-Amirhosseini, AF McDonagh, AL Burlingame, L Benet. Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry. Drug Metab Dispos... [Pg.191]

Disposition in the Body. Rapidly and almost completely absorbed after oral administration. Metabolised mainly by oxidation to inactive metabolites. More than 90% of a dose is excreted in the urine in 24 hours, mostly in the first 8 hours. The urinary material consists mostly of free and conjugated (glucuronide) 5-(4-carboxybenzoyl)-l-methylpyrrol-2-ylacetic acid and conjugated (glucuronide) tolmetin up to 15% is excreted in the urine as unchanged drug. [Pg.1032]

Ojingwa, J.C. Spahn-Langguth, H. Benet, L.Z. Studies of Tolmetin Reversible and Irreversible Binding to Proteins via Its Glucuronide Conjugates, Pharm. Res. 5(S2), 14 (1988). [Pg.312]

See other pages where Tolmetin glucuronide is mentioned: [Pg.152]    [Pg.3033]    [Pg.112]    [Pg.12]    [Pg.462]    [Pg.1463]    [Pg.66]   
See also in sourсe #XX -- [ Pg.670 ]



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