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Tolerance of neuromuscular blocking agents

3 times for 15 sec. Activity of 8-aminolevufinate synthase (ALA-S) is measured following the radiochemical method of Strand et al. (1972) with [14C]succinic acid and a succinyl-CoA-generating system. Enzyme activity is expressed as pmoles 8-aminolevufinic acid per 30 min per mg of protein. Ferrochelatase activity is measured using a modified radiochemical method (Bonkowsky et al. 1975 Deybach et al. 1981). [Pg.207]

To measure cytochrome P-450, 10 ml of the 800 g supernatant are centrifuged at 12 000 g for 15 min 5 ml of the supernatant are then centrifuged at 105 000 g for 30 min, after washing twice, microsomes (pellet) are resuspended in phosphate buffer and the protein concentration adjusted to 2 mg/ml. The level of cytochrome P-450 is measured in the microsomal fraction using the method of Omura Sato (1964). [Pg.207]

The tests allow judgement of the propensity of local anesthetics to induce symptoms of hepatic porphyria. The local anesthetics lidocaine, bupivacaine, etido-caine, mepivacaine, prilocaine and pyrocaine belong to this group, but procaine, butacaine, oxybuprocaine, proxymethacaine and tetracaine had no (or very slight) porphyrinogenic effect. [Pg.207]

Bayar Sumer (1995) investigated the effect of some local anesthetics on methemoglobin levels and erythrocyte enzymes. [Pg.207]

Anderson KE (1978) Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction. Biochem Biophys Acta 543 313-327 Bayar C, Sumer N (1995) The effect of some local anesthetics on methemoglobin levels and erythrocyte enzymes. Turk J Med Sci 26 439-443 [Pg.207]


See other pages where Tolerance of neuromuscular blocking agents is mentioned: [Pg.207]    [Pg.207]   
See also in sourсe #XX -- [ Pg.207 ]




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