Tolerance development cholinesterase inhibitors

If muscarinic effects of such therapy are prominent, they can be controlled by the administration of antimuscarinic drugs such as atropine. Frequently, tolerance to the muscarinic effects of the cholinesterase inhibitors develops, so atropine treatment is not required. 

Fonnum, F., Sterri, S.H. (2006). Tolerance development to toxicity of cholinesterase inhibitors. In Toxicology of Organ-ophosphate and Carbamate Compounds (R.C. Gupta, ed.), pp. lSl-61. Elsevier Academic Press, San Diego, CA. 

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