Tobacco alkaloids, nitrosamines derived from

Hecht, S.S. and A.R. Tricker Nitrosamines derived from nicotine and other tobacco alkaloids Chapter 11 in Analytical determination of nicotine and related compounds and their metabohtes, edited by J.W. Gorrod and P. lacob III, Elsevier, New York NY (1999) 421 88. Hecht, S.S., T.C. Tso, and D. Hoffmann Approaches to the reduction of nitrosamines and aromatic amines in Modifying the risk for the smoker. Proc. 3rd World Conf. on Smoking and Health, edited by E.L. Wynder, D. Hoffmann, and G.B. Gori, 1975, DHEW Publ. No. (NIH) 76-1221 (1976) 535-545. 

Figure 7. Some nitrosamines which can be derived from the tobacco alkaloids.

The formation of tobacco-specific nitrosamines from nicotine and related tobacco alkaloids under mild conditions suggested that they should be present in tobacco and tobacco smoke. Nicotine-derived nirosamino ketone (NNK) and hT-nitrosonornico-tine (NNN) have the properties of organ specificity in that the former induces lung tumours in rats and the latter nasal tumours, independent of the route of administration, these compounds are also effec-... 

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