13 Tnfluoromethyl estrogens

The condensation of 6 methoxy-1-vinyl-l-tetralol with 2-ttifluoromethyl-l 3 cyclopentanedione in the presence of a small amount of triethylamine produces a secodione (equation 104) This dione is an intermediate in the total synthesis of 13-tnfluoromethyl estrogens, such as 18,18,18-tnfluoro 17(3 estradiol [121] Regwselecnve alkylation of a fluorinated (3-disulfone occurs at low tempera ture [122] (equation 105)... 

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