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TNFa converting enzyme TACE

Another approach is the inhibition of the TNF-converting enzyme (TACE), which converts proTNF into its mature, proinflammatory form. Also, numerous inhibitors of P38 and Erk-MAP kinases have been synthesized and some have reached the clinical trial stage. MAP-p38 kinase occupies a central role in the signaling network responsible for the up-regulation of proinflammatory cytokines like interleukin 1 and TNFa. The pathway of Erk-MAP kinase is often up-regulated in human tumors and as such represents an attractive target for the development of anticancer drugs. ... [Pg.98]

See other pages where TNFa converting enzyme TACE is mentioned: [Pg.536]    [Pg.536]    [Pg.1248]    [Pg.275]    [Pg.276]    [Pg.270]    [Pg.1248]    [Pg.270]    [Pg.490]    [Pg.702]   
See also in sourсe #XX -- [ Pg.4 , Pg.182 , Pg.652 ]



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Converting enzyme

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