TMC-DLLA copolymers

The cylindrical porous scaffolds based on TMC-DLLA copolymers were prepared by salt-leaching method. Two-ply porous nerve guides were prepared by a combination of dip-coating (inner layer) and fiber-winding (outer layer) techniques. 

Potential Usage oe TMC-Based Copolymers in Tissue Engineering 8.5.4.1 TMC-DLLA Copolymers in Heart Tissue Engineering... 

In contrast to TMC-DLLA, the mechanical properties at equilibrium water uptake of TMC-CL copolymers are not significantly different from those in the dry state as shown in Table 8.1. 

Like the in vitro studies, the in vivo degradation of the TMC-CL copolymers containing 89% CL showed no change in shape or size after one year. As the degradation of the TMC-CL copolymers was so slow, a mature fibrous capsule remained throughout the year. Histological results of the TMC-CL copolymers were similar to those obtained from TMC-DLLA or other commonly used biodegradable polymers. 

Tsutsumi et al. reported the biodegradation of statistical copolymers composed of DL-Iactide or L-Iactide and cyclic carbonates in the presence of enzymes such as cholesterol esterase, hpoprotein hpase and proteinase K (Tsutsumi et al., 2002, 2003). All the enzymes exhibit degradative activity to the various copolymers. Biodegradation of P(DLLA-co-TMC) 87/13 and P(LLA-co-TMC) 71/29 is faster than that of PDLLA and PLLA using proteinase K which is known to degrade LLA moieties. 

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