Titrations protein surface receptors

A chylomicron or VLDL whose composition is optimized for lipolysis by LPL contains 10-20 molecules of apo C2/molecule of apo B. Titration of apo C2 levels against the rate of lipolysis has shown that no more than two or three apo C2 molecules per particle are needed for maximal TG hydrolysis rates. As lipolysis begins, and the surface area of the VLDL or chylomicron decreases, apo C proteins are displaced. This feature was probably developed to ensure that constant lipolysis rates of TG-rich lipoproteins are maintained until only small amounts of substrate remain, along with its apo B, apo E, and a few apo C proteins. The end-products of chylomicron and VLDL lipolysis ( remnants ) are removed by the liver via LDL receptors and other receptors (Chapter 20). 

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