Tissues and Latch Behavior

Isolated tissue has a characteristic behavior that has been extensively described. Stimulation of isolated 

POTENTIAL SITES OF REGULATION IN THE CROSS-BRIDGE CYCLE 

The basic mechanism for force generation is accepted to be the same in all three vertebrate muscle types the cyclic interaction between actin and myosin (Taylor, 1987). The binding of ATP to actomyosin (AM), hydrolysis of ATP, and eventual release from AM of ADP and Pj results in a large change in free energy that is translated into a force-producing conformation change and translocation of thin and thick filaments relative to one another. 

FIGURE 2 (A) Myosin ATPase cycle. MT, MD, and MDP indicate myosin species with an ATP, ADP, and 

Homogeneous versus Heterogeneous Populations of Cross-bridges 

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