Tissue engineering applications HEMA

MODIFIED HEMA HYDROGELS FOR TISSUE ENGINEERING APPLICATIONS... 

In particular, HEMA hydrogels have found widespread biomedical use mainly for the production of soft contact lenses . However, their surface properties must be modified to improve cell adhesion and proliferation in order to produce polymeric scaffolds suitable for tissue engineering applications. This objective can be achieved by introduction of charged groups onto the hydrogel surface. Accordingly, preformed HEMA hydrogels were reacted for 24 hours with succinic anhydride (SA) (Scheme 1) or 1,4-diaminobutane (DAB) in DMF solution (Scheme 2), at 50 and 100 °C, respectively. 

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