Tissue engineering applications biodegradable materials

As a biocompatible and biodegradable material, chitosan has found many and diverse medical, pharmaceutical, and therapeutic applications. Nevertheless, there is a lot of scope for improvisation in mechanical properties and biocompatibility of chitosan before it becomes an ideal biomaterial for tissue engineering applications. 

Insect and spider silks are natural biopolymers whose molecular structure enables their use in applications requiring exceptional strength and flexibility of the material. These traits along with their biocompatibility, biodegradability, and the ability to produce large amounts of the material make the use of silk and silk-based biomaterials a rational choice for a host of tissue engineering applications. 

Mo et al. prepared P(EEA-CE)-electrospun fibres where cells were well proliferated as monolayer cultures. Khatri et produced PCE-PEEA tubular nanofibres by electrospinning using different PCE-PEEA ratios to obtain good mechanical stability combined with faster biodegradability. They concluded that these materials are viable in tissue engineering applications, due to their biocompatibility, and can be considered as good substrates for in vivo or in vitro research. 

Ahedalwafa, M., Wang, F.J., Wang, L., li, CJ., 2013. Biodegradable poly-epsilon-caprolactone (PCL) for tissue engineering applications a review. Reviews on Advanced Materials Science 34, 123—140. 

---