Time to reach a given fraction of steady state

5 Time to reach a given fraction of steady state 

SM (ed.) (1970). Standard Math Tables, 18th edn. In non-linear elimination pharmacokinetics, the Chemical Rubber Co., Cleveland, OH, p. 397. time required to reach a given fraction of the integrals 27 and 30 to for the first two terms). 

Multiplying the first term by unity in the form of (V max - R)/(Vmax R) and expanding yields  

Multiplying both numerator and denominator of the logarithmic expression by -1 yields  

If the objective is to determine how much time it will take to reach a given fraction of the drug 

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