Tibia Metaphyseal

Thirty-seven weeks after ovariectomy, marked decreases of 73% (p <. 01) and 77% (p <. 01) in trabecular bone volume and trabecular bone number (data not shown), respectively, were observed at 1 to 5 mm of the growth plate metaphyseal junction of the proximal tibia. Simultaneously, a marked increase in trabecular bone separation from a control value in intact rats of 262 19 to 1486 236 pm (p <. 01) was observed in OVX animals. Treatment with 1 mg/kg of EM-800 and raloxifene resulted in 68% (p<. 01) and 64% (p <. 01) reversals, respectively, of the decrease in trabecular bone volume caused by ovariectomy. In fact, treatment with EM-800 and raloxifene at the daily 1 mg/kg dose increased trabecular bone volume of the proximal tibia from a control value of 5.8 0.9% in OVX animals to 16.4 0.4% and 15.8 1.0%, respectively. These stimulatory effects are not statistically different from the 53% reversal achieved with E2. At the lowest dose used (0.01 mg/kg), EM-800 already reversed by 34% (p <. 01) the elfect of OVX whereas raloxifene had no detectable effect. The administration of 0.1 mg/kg of EM-800 and raloxifene, on the other hand, resulted in 40% (p <. 01) and 24% (p <. 05) reversals, respectively, of the decrease in trabecular bone volume caused by OVX. 

Fig. 10.10. a AP radiograph of the left knee showing metaphyseal fracture of both the distal femur and proximal tibia, b Lateral radiograph of the same patient shows periosteal reaction around the proximal tibia due to healing... 

Fig. 21.16. Scurvy. Marginal metaphyseal fractures (Pelkan spurs) distal femur and distal tibia. The differential diagnosis includes non-accidental injury...

These subtypes affect males slightly more frequently than females and have their peak incidence in the second decade of life. They occur most frequently in the metaphyses of the distal femur, the proximal tibia, and the proximal humerus. The most favorable group with high-grade histology is the classical osteosarcoma demonstrated in a young patient with localized tumor in the extremity without evidence... 

---