Tiagabine drug interactions

Drug Interactions. Enzyme inducers, such as carbamazepine and phenytoin, increase tiagabine clearance and decrease the half-life. Food decreases the rate but not the extent of absorption. Tiagabine is displaced from protein by naproxen, salicylates, and valproate. However, tiagabine does not displace phenytoin, valproic acid, amitrypty-line, tolbutamide, or warfarin. ... 

Because of its inducing effect on hepatic enzymes, phenobarbitai has many drug interactions, decreasing plasma levels of CBZ, valproate, lamotrigine, tiagabine, zonisamide, warfarin, theophylline, cimetidine, and those of other CYP3A4 substrates. Serum concentrations of phenobarbitai are increased by valproate. 

KastbergH, Jansen JA, ColeG, WesnesK. Tiagabine absence ofkinetic or dynamic interactions with ethanol. DrugMetdbol Drug Interact 99Z) 14,259-73. 

Gustavson LE, Sommerville KW, Boellner SW, Witt GF, Guenther HI, Granneman GR. Lack of a clinically significant pharmacokinetic drug interaction between tiagabine and valproate. AmJTher 99%) 5, 73-79,... 

Richens A, Ivtiirshdll RW, Dirach J, Jansen JA, Snel S, Pedersen PC. Absence of interaction between tiagabine, a new antiepileptic drug, and the ben xliazepine triazolam. DrugMetol Drug Interact ( m) 14,159-77. 

Drug-drug interactions Tiagabine An interaction of gemfibrozil with tiagabine has been reported [19 ]. 

Drug/Food interactions A high-fat meal decreases the rate, but not the extent (AUC), of tiagabine absorption. 

I Advantages. Tiagabine has a specific, known mechanism of action. It is the first drug marketed in the United States that acts only on GABA reuptake. This drug has linear pharmacokinetics and is not reported to interact with other drugs. 

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