Thyroxine calorigenic activity

Jorgensen EC, Zenker N, Greenberg C. et al. Thyroxine analogues. III. Antigoitrogenic and calorigenic activity of some alkyl substituted analogues of thyroxine. J Biol Chem 1960 235 1732-1737. 

Synthetic racemic thyroxine has been resolved and the biological properties of both antipodes, the natural levorotatory (L-T4) and the dextrorotatory D-T4) forms, have been evaluated. L-T4is about 10 times more active than D-T4 [180]. At the present time D-T4 appears to be the only th5n oid analog accepted by some cHnicians as a hypocholesterolemic agent. It is claimed that D-T4 exerts approximately one-twentieth the calorigenic activity of L-T4 in man whereas the cardiac-stimulating activity is purported to be only 1-2% that of L-T4 [181]. 

Due to the available structure-activity relationship data accrued on thyroxine type compounds, a body of knowledge is now available which permits the medicinal chemist to approach the synthesis of analogs of thyroxine with the object of dissociating hypolipidemic activity from the calorigenic and cardiotropic prop-... 

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