Thyroid hormone response elements TREs

Model of the interaction of T3 with the T3 receptor. A Inactive phase —the unliganded T3 receptor dimer bound to the thyroid hormone response element (TRE) along with corepressors acts as a suppressor of gene transcription. B Active phase — T3 and T4... 

Figure 16.31. The Promoter of the Phosphoenolpyruvate Carhoxykinase Gene. This promoter is approximately 500 bp in length and contains regulatory sequences (response elements) that mediate the action of several hormones. IRE, insulin response element GRE, glucocorticoid response element TRE, thyroid hormone response element CREI and CREII, cAMP response elements. [After M. M. McGrane, J. S Jun, Y. M. Patel, and R. W. Hanson. Trends Biochem. Sci. 17(1992) 40.]...

This promoter is approximately 500 bp in length and contains regulatory sequences (response elements) that mediate the action of several hormones. Abbreviations IRE, insulin response element GRE, glucocorticoid response element TRE, thyroid hormone response element CREI and CREII, cAMP response elements. 

Thyroid response elements TRE A domain on deoxyribonucleic acid (DNA) that will bind the complex formed by thyroid hormone binding to the thyroid hormone receptor. When the complex binds to the TRE, which are located in the promoter region of the DNA, it activates transcription of the gene. When thyroid hormone is not bound to the receptor the receptor acts as a transcription repressor. 

A FIGURE 11-42 Consensus sequences of DNA response elements that bind three nuclear receptors. The response elements for the glucocorticoid receptor (GRE) and estrogen receptor (ERE) contain inverted repeats that bind these homodimeric proteins. The response elements for heterodimeric receptors contain a common direct repeat separated by three to five base pairs, for the vitamin D3 receptor (VDRE), thyroid hormone receptor (TRE), and retinoic acid receptor (RARE). The repeat sequences are indicated by red arrows. [See K. Umesono etal., 1991, Ce//65 1255, and A. M. Naaretal., 1991, Ce//65 1267]... 

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