Thymine DNA glycosylase

TDG Thymine-DNA glycosylase Removes U, T, or etheno-C opposite G (preferably CpG sites)... 

Deamination of 5-methyl-cytosine results in the formation of a T C mispair. This mispair is slowly repaired by a special enzyme, which slowly hydrolyzes the residue of T. The enzyme is called thymine DNA glycosylase (Neddermann and Jiricny, 1993). 

Neddermann, R, and Jiticny, J. (1993). The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. /. Biol. Chem. 268, 21218-21224. 

J.N., and Cao, W. (2008) Repair of deaminated base damage by Schizosac-charomyces pombe thymine DNA glycosylase. DNA Repair, 7,1962-1972. 

Coordinating the initial steps of base excision repair. Apurinic/ apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex. J. Biol. Chem., 283, 32680-32690. 

Hardeland, U., Steinacher, R., Jiricny, J., and Schar, P. (2002) Modification of the human thymine-DNA glycosylase by ubiquitin-like protein facilitates... 

Steinacher, R. and Schar, P. (2005) Functionality of human thymine DNA glycosylase requires SUMO-regulated changes in protein conformation. Curr. Biol, 15, 616-623. 

DNA metabolism Flap endonuclease-1, thymine DNA glycosylase, Werner DNA helicase... 

Chen, D., Lucey, M. J., Phoenix, F., Lopez-Garcia,J., Hart, S. M., Losson, R., Buluwela, L., Coombes, R. C., Chambon, P., Schar, P., and Ali, S. (2003). T G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. J. Biol Chem. 278, 38586-38592. 

Waters, T. R., Gallinari, P., Jiricny, J., and Swann, P. F. (1999). Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1./. Biol Chem. 274, 67—74. 

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