Thrombosis abnormal hemostasis

Hemostasis is the process of blood clot formation at the site of vessel injury. When a blood vessel wall breaks, the hemostatic response must be rapid, localized, and carefully regulated. Abnormal bleeding or a propensity to nonphysiologic thrombosis (i.e., thrombosis not required for hemostatic regulation) may occur when specific elements of these processes are missing or dysfunctional. The elements responsible for normal hemostasis have received extensive review. 

Excessive bleeding and thrombosis may represent altered states of hemostasis. Impaired hemostasis results in spontaneous bleeding stimulated hemostasis results in thrombus formation. The drugs used to arrest abnormal bleeding and to inhibit thrombosis are the subjects of this chapter. 

Baronzio G, Freitas 1, Kwaan HC (2003) Tumor microenvironment and hemorheological abnormalities. Sem Thrombosis Hemostasis 29 489-497... 

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