Thrombosis A Dark Side of Hemostatic System Function

Thrombosis A Dark Side of Hemostatic System Function 

Formation of a hemostatic plug or a red thrombosis (fibrin and entrapped red blood cells) at a site at which there is no injury produces occlusion. Death to the surrounding tissues can occur (infarction), or pieces of the thrombus may be tom away and moved to the lungs, producing pulmonary embolism. Such dysfunction of the hemostatic system is generally not attributable to a single cause. For example, heterozygous individuals with half of the normal amount of protein C do not necessarily present with 

Estrogen therapy has been linked to changes in the concentrations of several components of the hemostatic system. However, there are no changes in components of the procoagulant, anticoagulant, or fibrinolytic system that can be clearly linked to an increase in risk of thromboembolic disease sometimes associated with estrogen therapy. 

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