Thromboembolic disorders pregnancy

Active thrombophlebitis or thromboembolic disorders undiagnosed abnormal genital bleeding known or suspected pregnancy acute liver disease benign or malignant... 

CAUTION. Not recommended in patients with known or suspected cancer of the breast known or suspected estrogen-dependent neoplasia undiagnosed abnormal genital bleeding thrombophlebitis or thromboembolic disorders or a previous case-history of such typical conditions and hypersensitivity to the ingredients of the cream or suppositories of dienestrol or during pregnancy. 

Contraindications Pregnancy (teratogenic), estrogen dependent neoplasm, vaginal bleeding, liver impairment, thromboembolic disorders. 

Thrombosis in the dural sinuses or cerebral veins is much less common than cerebral arterial thromboembolism. It causes a variety of clinical syndromes, which often do not resemble stroke (Bousser and Ross Russell 1997). While ischemic arterial stroke and cerebral venous thrombosis share some causes (Southwick et al. 1986), others are specific to cerebral venous thrombosis (Table 29.1). A particularly high index of suspicion is required in women on the oral contraceptive pill (Saadatnia and Tajmirriahi 2007) and in the puerperium. In the past, cerebral venous thrombosis was strongly associated with otitis media and mastoiditis, lateral sinus thrombosis or otitic hydrocephalus, but the most common causes are now pregnancy and the puerperium, which cause 5-20% of the cerebral venous thrombosis in the developed world, the oral contraceptive pill, malignancy, dehydration, inflammatory disorders and hereditary coagulation disorders. No cause is found in around 20% of cases. 

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