Thrombogenesis thrombin

Procoagulcmt Activity. EMPs, similar to other MPs, have been demonstrated to readily induce thrombogenesis [5, 33]. In this regard, EMPs have been shown to be procoagulant in a TFrFVII-dependent manner [51]. In addition, they have been shown to elicit thrombin generation and to provide platelet factor 3 activity, as reviewed [5]. EMPs have also been shown to carry other important proteins such as PA-1 and vWF on their surface [56, 57]. 

Critical role of thrombin in thrombogenesis. Thrombin plays a critical and central role in thrombogenesis through platelet activation, fibrin generation, and clot stabilization at the site of arterial disruption, which are caused by percutaneous coronary intervention or plaque rupture in acute coronary syndromes. 

Imaging of enzyme activities Thrombin, a serine protease, plays an important role in thrombogenesis, cleaving fibrinogen to form fibrin monomers, which subse-... 

Since thrombin is formed upon the surface of stimulated platelets (20). and since Hageman Factor is activated at artificial surfaces (21). thrombin is likely to be preferentially formed at a surface during mural thrombogenesis with whole blood. It would then be open to the influence of convection and diffusion in a manner similar to... 

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