Thrombin-antithrombin complex TAT

Thrombin-antithrombin complex (TAT) concentrations were measured using a specific radioimmunoassay . 

Thrombin-antithrombin complexes (TAT) stress markers, it is clear that OP intoxication represents a stress situation. In this context, an increase in Alanine aminotransferase (ALT) can also be considered as a stress marker and not indicative of liver damage. 

Figure 13.10. Thrombin-antithrombin III complex, TAT, concentration versus time of contact with PVC containing two plasticizers (di-(2-ethylhexyl) phtha-late, DOP, and tri-(2-ethylhexyl) trimellitate, TOM). [Adapted, by permission, from Yin FI Q Zhao X B Courtney J M Blass C R West R FI Lowe G D O, J. Mater. Sci. Mater Medicine, 10, No.9, Sept. 1999, p.527-31.]...

The adsorption of the thrombin-antithrombin (TAT) complex on the polymer surface was also examined in plasma. The study was conducted as the AT adsorption was and the results are reported in Fig. 3 for normal plasma and defibrinated plasma. No significant differences can be seen between the two sets of experiments which... 

In previous papersl> the antithrombic activity of these polymers was demonstrated to involve one (or several) plasma cofactor as for instance antithrombin III. The catalytic effect of the polymers on the thrombin-AT reaction was evaluated by comparison of the TAT amounts generated during 10 seconds in presence or absence of polymer. In each case, the polymer suspension - or buffer - was first incubated with fresh platelet poor plasma. Then thrombin was introduced and after 10 seconds the reaction was blocked by addition of hirudin. The Fig. 5 shows a typical variation of TAT generation as a function of the amount of polymer present in the test. The TAT levels were measured in the supernatant bbtained by centrifugation of the final suspension and the results are expressed in percent of the maximum.of TAT complex which can be... 

---