Thiophilic ligand structures

TABLE 10 Main Thiophilic Ligand Structures Described for the Separation of Antibody... 

Fig. 1 Structure of the thiophilic ligand created by the reaction of 2-mercaptoethanol with divinyl sulfone-activated agarose. Immunoglobulins bind to the adjacent sulfone and thioether groups.

Complex aminoacid sequences structure Thiophilic like ligands Hydrophobic charge transfer effect... 

Heterocyclic structures acting as thiophilic sorbents for the separation of immunoglobulins have also been described. In 1988 Porath and Oscarsson157 described several structures involving thiophilic electron-donor-acceptor mechanism. Pyridyl sulfide and phenyl sulfide molecules were attached to agarose beads and then used for the separation of plasma proteins. All these ligands adsorbed preferably immunoglobulins. 

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