Thiophene-2,4-disulfonyl chloride

The sulfonation of 2-acetamidomcthylthiophene and of 2-acetami-dothiophene attracted considerable interest in connection with work on potential thiophene chemotherapeutics, although from this point of view these investigations have given little reward. Sulfonation of 2-acetamidomethylthiophene with chlorosulfonic acid occurs in the 5-position. At room temperature 100% sulfuric acid yields 80% 5-acetamido-2-thiophcnesulfonic acid. With chlorosulfonic acid sulfonation cannot be stopped at the monosubstitution stage and 2-acetamido-3,5-thiophene disulfonyl chloride is obtained. - In recent Russian work the isolation of a monosulfonated product is claimed, however. With the activating -f-M-substituents, disubstitution, which is easily achieved, always leads exclusively to 3,5-disub-... 

Thiophene disulfonyl chloride, 2-acetamido-, 50 Thiophene sulfone, 106 Thiophene sulfoxide, 106... 

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