Thiophene-C-X Compounds Thenyl Derivatives

The unit - thiophene linked to a carbon - is termed thenyl, hence thenyl chloride is the prodnct of chloro-methylation (17.1.1.7) thenyl bromides are nsnally made by side-chain radical substitution, snbstitntion at an a-methyl being preferred over a P-methyl. ° 

Relatively straightforward benzene analogue reactivity is found with thenyl halides, alcohols (conveniently preparable by reducing aldehydes) and amines, from, for example, reduction of oximes. One exception is that 2-thenyl Grignard reagents usually react to give 3-substituted derivatives, presumably via a non-aromatic intermediate.  

Relatively straightforward benzene-analogue reactivity is found with thenyl halides, alcohols (conveniently preparable by reducing aldehydes) and amines, 

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