Thiopental absorption/distribution

What is the difference between the drugs thiopental and pentobarbital and how would it affect their absorption and distribution ... 

A drug-induced change in the distribution and renal excretion of sulfonamides, JPET, 134, 291-303 (1961). Mayer et al. also reported values for thiopental (7.6), aniline (4.6), aminopyrine (5.1), 4-aminoantipyrine (4.1), acetanilide (1.0), barbital (7.8), N-acetyl-4-aminoantipyrine (NAAP 0.5), salicylic acid (3.0). With the exceptions of acetanilide and NAAP, all additional pKa values were obtained by the potentiometric method. The barbital value is lower than the best value and suggests that carbon dioxide absorption interfered, however, the remaining values should not be affected by this factor. 

Pharmacokinetic constants for the absorption and elimination of pralid-oxime have been determined in man83. a pharmacokinetic model for flow, lipid solubility, protein binding and saturation-IImited metabolism of thiopental has permitted the a priori prediction of bodily distribution conslsten with experiment . Imipramine and its metabolites are rapidly distributed in the rat and renally and biliary excreted with enterohepatic circulation . Mathematical models have been established for the pharmacokinetics of neurohypophysial and related peptides . The oral administration of 2,3,5, triiodebenzoic acid in goats and a cow by whole-body radioactivity retention showed a rapid distributive and subsequent exponential elimination phase with the metabolites formed by deiodination . Bishydroxycoumarin shows dose-dependent first order elimination in man but not in other species and has been assigned to dose effects on el imi nation . ... 

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