Thiolation cystamine

More recently, thiolated dextran was synthesised by modification of dextran with 4-nitrophenyl chloroformate in DMSO/pyridine in the presence of DMAP at 0 °C yielding a carbonate (content 6%), which can be substituted with cystamine. Subsequent reduction yields the thiolated dextran containing between 1 and 4% thiol moieties (Fig. 57) [370]. 

---