Thiohydantoins, solution-phase

Ohberg, L. and Westman, J., One-pot three-step solution phase syntheses of thiohydantoins using microwave... 

In another heterocycle forming procedure, Westman et al. (see Chapter 5) employed microwave dielectric heating to a sequential one-pot, three-step reaction sequence leading to an array of structurally diverse thiohydantoins (Scheme 6.28)165. Although the final sequence is a purely solution-phase protocol, involving no immobilised reagents,... 

Figure 8.11 Synthetic scheme to the solution-phase, discrete thiohydantoin library L2.

An efficient one-pot protocol has been developed for the solution-phase synthesis of thiohydantoins (Scheme 4) [10]. After reductive alkylation of amino acid esters 16, the isothiocyanate was added together with triethylamine, leading to thiohydantoin products 18. The work-up procedure was performed by adding gly-... 

MM Sim, A Ganesan. Solution-phase synthesis of a combinatorial thiohydantoin library. J Org Chem 62 3230-3235, 1997. 

Application of effective parallel purification methods continues to improve the quality of products prepared using solution phase approaches. Sim and Ganesan [14] developed a one-pot three component synthesis of thiohydantoins using the reductive am-... 

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