Thioguanylic acid

Chromatographic evidence has been obtained for the formation of 6-thioguanosine di- and triphosphates in Ehrlich ascites cells [197] and their formation is supported by the demonstrated incorporation of thioguanine into nucleic acids as thioguanylic acid [198]. The incorporation of both the a- and 3-anomers of 2 -deoxythioguanosine (XXXVI) [199] into DNA without... 

Another guanine analogue, thioguanine, is also incorporated into both DNA and RNA of mammalian cells [198], and a correlation between its antitumour activity and the extent of its incorporation into DNA has been observed [339,340], although some investigators feel that the metabolic effects of thioguanylic acid may be more universally important [13, 91, 341]. The incorporation of a- and... 

Disposition in the Body. Incompletely and variably absorbed after oral administration. Rapidly activated by intracellular conversion to thioguanylic acid. Inactivated by methylation to aminomethylthiopurine and by deamination to thioxanthine. About 40% of an oral dose is excreted in the urine as metabolites in 24 hours only traces of thioguanine have been detected. 

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