Thioate anion

Hydrolysis studies with the thioated anions (9.639a,b) indicate that the monomeric thiometaphosphate anion (9.639c) is formed as a short-lived intermediate during the course of the reaction. 

There are sulfur analogues to some of the types of oxo-acids and esters, many of which have been extensively studied,46 and some of which have important industrial uses. The most important of these are the dithiophosphinates (or phosphinodi-thioates) and the dithiophosphates which are the anions of R2P(S)SH and (RO)2PS(SH), respectively. The dithiophosphates are essential additives to motor oils. They are easily made ... 

Fully thioated hypophosphate derivatives are relatively stable and several well-characterised salts, M2P2S6, where M is a divalent metal, and MP2S< , where M is a tetravalent metal, are known [16,17]. These salts can be made by double decomposition from the soluble tetrasodium salt, which itself can be obtained from sodium sulphide and phosphorus trichloride. Some can be made by direct reaction between red P and metal or its sulphide (9.529,9.530). Many anions based solely on P and S are now known (Table 9.5) [42]. 

Normal oligonucleotides are analyzed by reverse-phase, anion-exchange, and PAGE. Thioated oligonucleotides can be analyzed by RP-HPLC and PAGE. For anion-exchange analysis, the terminal 5 -DMT group should be removed either with 80% acetic acid after deprotection... 

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