2-Thio-5- uridine

The site B, has been established by three-dimensional electron density maps for UpcA, 3 -CMP, 3 -UMP, 2 -CMP, d-TpT, and 4-thio uridine. The site B2 has similarly been demonstrated for the adenine in UpcA (526a), 3 -AMP, 5 -AMP, 3 5 A > p, and ATP. The two sites can be occupied simultaneously or independently by 3 -AMP and 3 -CMP with no strong interaction. The Bj site has also been demonstrated for 3 -CMP and 3 -UMP in the DNP-Lys 41 derivative. Electron density has appeared at the B2 site in high concentrations of pyrimidines and in the inferred digestion products of UpU in the DNP-Lys 41 crystals. 

First side-directed spin labeling (SDSL) studies date back to the early 1970s. There, tRNAs were subjected to nitroxide labeling via either naturally occurring rare nucleobases, e.g., 2-thio-uridine, enzymatically introduced nucleobases such as... 

Nucleosides, Nucleotides, Derivatives, and Related Compounds. — 5-Substituted uracils were examined for conformational dependence on the substituents, uridine 5 -phosphate disodium salt, 2 -deoxyuridine 5 -phosphate disodium salt, " 6-methyl-2 -deoxyuridine, 5-C-acetyl-2 -deoxyuridine, dihydrouridine 3 -phosphate potassium salt, 5-hydroxymethyl-2 -deoxyuridine, 4-thio--uridine, 2,5 -anhydro-2, 3 -0-isopropylidene-2-thiouracil, 2,2 -an-hydro-1 - 3-D-arabinofuranosyl-2-thiouracil. ... 

Fox s group has extended its work on the synthesis of pseudocytidine ( -cyti-dine) (Vol. 9, p. 148) to include other 5-D-ribofuranosylpyrimidines. Thus the 3-methoxyacrylate derivative (436) reacted with guanidine, urea, or thiourea to give derivatives of i -cytidine, -uridine, and 2-thio- -uridine and their a-anomers. The D-ribofuranosyl-ethyne and -ethene derivatives (437) and... 

Uric acid, 9-methyl-2,8-dithio-, 5, 590 Uric acid, 9-phenyl-synthesis, 5, 577 Uric acid, 8-thio-synthesis, 5, 577, 582 Uric acid, 1,3,7-trimethyl-ethylation, 5, 534 methylation, 5, 535 Uric acid, 1,7,9-trimethyl-methylation, 5, 535 Uridine... 

CnH17N305S 2 HaO 2-Thio-5-(methylaminomethyl)uridine, dihydrate (TMAMUR10)168... 

PYRIDIVITE PYRIPYRIDIUM PYRIZIN SEDURAL SULADYNE SULODYNE THIO-SULFIL-A FORTE URAZIUM URIDINAL ... 

Graham, L L, Whistler, R L, Uridine 5 -(5-Thio-a-D-glucopyranosyl pyrophosphate) chemical synthesis and activation of rat liver glycogen synthetase. Biochemistry, 15, 1189-1194, 1976. 

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