Thio-substituted compound reductions

Kempter and co-workers prepared benzodiazocines 134 (R = R1 = H R2 = H, Me) from 135 (R = H, Me) by reduction and subsequent cyclo-condensation with the appropriate carbonyl compound (75MI7 87ZC36). For example, these workers condensed 3-(o-aminophenyl)propylamine with either phosgene or alkyl chloroformate to obtain 134 (R = R1 = R2 = H, X = O). Reaction of the same diamine (77MI5 87ZC36) and substituted derivatives (77MI5) with carbon disulfide afforded thio-... 

With few exceptions, derivatives of tervalent phosphorus acids are prepared from phosphorus trichloride by nucleophilic substitution of one or two of the chloro groups with organometallic compounds, followed by substitution of the remaining chloro groups with alkoxy, amino, alkylthio groups, etc., or vice versa (Scheme 1). Occasionally a tervalent compound is best obtained by reduction of a (thio)phosphoryl derivative which is prepared from (thio)phosphoryl chloride (Scheme 2), or from a P—H compound and an electrophilic reagent, e.g. Scheme 3. 

Pyrrole- and Furan-fused Thio diens and Related Compounds.— The interest in the chemistry of thienopyrroles is still increasing. Starting from 2-amino-3-carbonyl-substituted thiophens obtained by the Gewald reaction, the A -ethoxy-carbonylmethyl derivative (245) was prepared either by direct alkylation with ethyl bromoacetate, or by reductive alkylation with methyl glyoxalate. The compounds (245) were then ring-closed directly, or after acetylation, to the... 

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