Thio-linked oligosaccharides

Fan, L. F. Hindsgaul, O., Synthesis of novel cyclic oligosaccharides beta-l,6-thio-linked cycloglucopyranosides. Org. Lett. 2002,4, 4503-4506. 

A major use for 1-thio- and 1-seleno-glycosides is in the synthesis of O-linked glycosides and oligosaccharides.101... 

Although solid-phase chemistry is well developed, progress has not yet been fully extended to oligosaccharide chemistry, because of the high demands on the polymer support and the lack of powerful analytical tools for monitoring reactions on solid phases. The synthesis of an a(l-2)-linked pentamannose moiety has recently been reported (Scheme 45) [193] a Merrifield resin, a thio-linker, and a 2-0-acetyl protected mannosyl trichloroacetimidate were used. The glycosylation reaction was... 

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