Thietanes, p-sultams, and related systems

A novel one-step synthetic route for the construction of fully substituted pyrazol-4-ols by the condensation-fragmentation-cyclization-extrusion reactions of thietanone 62 with 

The asymmetric synthesis of c -3,4-disubstituted P-sultams 65, based on the oxidation of 1,2-aminothiols with H2O2 and ammonium heptamolybdate has been achieved 05S1807 . Different transition-state structures for the reactions of P-lactams and their sulfonyl analogues P-sultams with serine P-lactamases have been reported 05JA17556 . It has been discovered that the 3-oxo-P-sultam 66 is unusual in that it inhibits elastase by acylation resulting from substitution at the carbonyl center, C-N fission, and expulsion of the sulfonamide 05JA8946 . 

---