Elastase, inhibition

Micrograms of elastase inhibited after incubation for lOmin at 37°C per microgram of a-l-PI (measured immunologically) in concentrated BAL fluid mean of at least three measurements 1 SD. 

B-Lactamase inhibitors, 31 (1994) 297 Leprosy, chemotherapy, 20 (1983) 1 Leukocyte elastase inhibition, 31 (1994) 59 Leukotriene D4 antagonists, 38 (2001) 249 Ligand-receptor binding, 23 (1986) 41 Linear free energy, 10 (1974) 205... 

Table 1 The effectiveness of 0.1% experimental agent as a leukocyte elastase inhibitor in comparison to selected elastase-inhibiting agents...

Elastase, inhibition, 31 (1994) 59 Electron spin resonance, 12 (1975) 191 Electrophysiological (Class III) agents for arrhythmia, 29 (1992) 65 Endorphins, 17 (1980) 1 Endothelin inhibition, 31 (1994) 371 Enkephalin-degrading enzymes, 30 (1993)... 

An alternative therapy for anaphylactic shock and asthma is represented by tibenelast (64) which is orally effective by a poorly defined mechanism of action <90LS917>. A later study showed (64) to be a selective phosphodiesterase inhibitor <90MI 212-06>. Elastase inhibition also has potential in the treatment of insufficient lung function MR 889 (65) is an inhibitor of human leukocyte elastase and may have therapeutic utility for pulmonary emphysema <89BBR(I65)568>. Neltenexine (66) has recently been approved for the treatment of cystic fibrosis. 

Dialkylidenecephalosporin sulfones 92 are reported to be potent class C lactamase inhibitors <00T5709> and other cephalosporin sulfones show human elastase inhibiting abilities <00CHE1232, 01EJM185>. Many novel cephalosporins have been reported as a... 

It shows elastase inhibition, so it is used as antiinflammatory agent as well as an anti-degenerative agent. 137... 

Le-Barillec K, Si-Tahar M, Balloy V, Chignard M. Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation. J Clin Invest 1999 103 1039. 

The C-terminal domain of human macrophage elastase inhibited elastin degradation (Gronski jr. et al. 1996). 

Borzeix F, Hillion G, Marchal R, Stoltz C. Use of a sophorolipid to provide free radical formation inhibiting activity or elastase inhibiting activity 1998. Patent US 5756471 A. 

Edwards, J., Bopp, A. F., Batiste, S. L., Goynes, W. R. (2003). Human neutrophil elastase inhibition with a novel cotton-alginate wound dressing formulation. Journal of Biomedical... 

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