1.3- thiazoles, microwave-assisted synthesis

Khan et al. [9] reported the environment friendly microwave-assisted synthesis of substituted steroidal[6,7-d]thiazoles (iv). The key step involved the reaction of a-haloketones (iii) and thiourea/substituted thiourea via hantzsch protocol. 

Frere, S., Thiery, V. and Besson T., Eco-friendly microwave-assisted scaleable synthesis of 2-cyanobenzo-thiazoles via N arylimino 1,2,3 dithiazoles, Synth. Commun., 2003, 33, 3789-3798. 

The synthesis of oxygen-heterocycles by intermolecular reactions of a-TK with nucleophiles has received only limited attention. However, a-tosyloxy derivatives of several acetophenones have been prepared by brief exposure of neat HTIB/ketone mixtures to microwave (MW) radiation, and employed on mineral oxide surfaces for microwave-assisted syntheses of thiazoles and 2-aroylbenzofurans 40 (Scheme 11) (98JCS(P1)4093, 99JHC1565). 

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