Thiazoles, 2-fluoro-, synthesis

The easy ring-opening quality of hexafluoro-1,2-epoxypropane in the presence of a nucleophile has been used to accomplish the synthesis of imidazo[2,l-ft]thiazol-3(2//)-one. Thus, the sodium salt of 4,5-diphenylimidazolyl-2-thione (16, R1 = R2 = Ph) reacts with hexafluoro-1,2-epoxypropane in acetonitrile to furnish 5,6-diphenyl-2-fluoro-2-triflu-oromethylimidazol2,l-b]thiazol-3(2W)-one (18f) in a one-step synthesis (78BCJ3091). 

Sokolenko TM, Davydova YA, Yagupolskii YL (2012) Efficient synthesis of 5 -fluoro dkoxy-thiazoles via a-bromo-a-fluoroalkoxyacetophenones Hantzsch type cyclization with thioureas or thioamides. J Fluorine Chem 136 20-25. doi 10.1016/j.jfluchem.2012.01.005... 

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