Thiazides adverse reaction

Additional adverse reactions of these drugs are listed in tiie Summary Drug Table Diuretics. When a potassium-sparing diuretic and a thiazide diuretic are given together, tiie adverse reactions associated with both drugp may be seen. 

Administration of thiazides and related diuretics may be associated with numerous adverse reactions. However, many patients take these drug s without... 

Nine randomized, controlled studies of the use of diuretics in pre-eclampsia have been analysed (145). There were almost 7000 subjects in whom thiazides had been compared with placebo or no treatment. In the pooled analysis, diuretic treatment was associated with a nonsignificant reduction in perinatal mortahty (about 10%) and stillbirths (about 33%). There was no excess of serious adverse reactions, either in the mothers or the neonates. These findings thus give no support to the belief that diuretics are harmful in pregnancy. It should not be concluded that diuretics ought to be used in pre-eclampsia in preference to other well-established agents, but they certainly can be used with confidence when they are really needed, for example in patients with severe hypertension that predates pregnancy and in heart failure. 

Adverse reactions to allopurinol, particularly toxic epidermal necrolysis and a hypersensitivity syndrome, are reputed to be more common in patients taking thiazides, but evidence to support this is hard to find (SEDA-11, 198) (SEDA-13,188). 

Brown CW Jr., Deng JS. Thiazide diuretics induce cutaneous lupus-hke adverse reaction. J Toxicol Chn Toxicol 1995 33(6) 729-33. 

Side effects and adverse reactions of thiazides are electrolyte imbalances, hyperglycemia, hypemricemia (elevated serum uric acid level), and hyperUpi-demia (elevated blood lipid levels). They affect the metaboUsm of carbohydrates. 

Adverse reactions Hyperkalemia leading to arrhythmias, nausea, vomiting, headaches, weakness, fatigue, bowel disturbances, cough and dyspnea Thiazide... 

Brown, C. W. and Deng, J. S., Thiazide diuretics induce cutaneous lupus-like adverse reaction, /. Toxicol. Clin. Toxicol, 33,729,1995. 

---