Thiamin diphosphate pyrimidine, role

Vitamin Bi (also called thiamine) is a water-soluble vitamin of B complex present in many foods as a natural nutrient. It is a biologically and pharmaceutically important compound containing a pyrimidine and a thiazole moiety such as 4-amino-5-hydroxymethyl-2-methyl-pyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole linked by a methylene bridge (Figure 15.1). It is necessary for carbohydrate metabolism and for the maintenance of neural activity because most of the humans and mammals cannot synthesize vitamin Bi. Nerve cells need vitamin BI for their normal function because vitamin Bi has diphosphate-active sites which serve as a cofactor for several enzymes (Leopold et al. 2005). Vitamin Bi is employed for the prevention and treatment of beriberi, neuralgia, etc. and played a vital role in enzymatic mitochondrial... 

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