1,3,4-thiadiazoles, microwave-assisted

The microwave-assisted solid-supported synthesis of 1,3,4-thiadiazoles was described applying from acid and thiosemicarbazide on acidic aliunina... 

Kidwai, M., Kumar, P., Goel, Y. and Kumar, K., Microwave assisted synthesis of 5-methyl- 1,3,4-thiadiazol-2-ylthio/tetrazol-l-yl substituted pyrazoles, 2-azetidinones, 4-thiazolidinones, benzopyran-2-ones and 1,3,4-oxadiazoles, Indian. J. Chem., Sect. B, 1997, 36, 281. 

Scheme 6.21 Microwave assisted convenient synthesis of 7-(5-alkyl-l,3,4-thiadiazol/oxadiazol-...

Fordyce et al. (2010) have enveloped an improved method for the synthesis of isothiazoles and 1,2,4-thiadiazoles. The 1,3-dipolar cycloaddition reactions of nitrile sulfides, generated by microwave-assisted decarboxylation of 1,3,3-oxathiazal-2-ones have been studied. The adducts l,2,4-thiadiazole-5-carboxylates were synthesized by cycloaddition of the nitrite sulfides to ethyl cyanoformate. 

Labrini et al. (2005) have reported a rapid synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via the one pot condensation reaction of aromatic aldehydes, hydrazine, and sulfur in ethanol under microwave irradiation. Microwave-assisted synthesis of 2-aminothiophene-3-carboxylic derivatives (Gewald synthesis) has been reported by Hu et al. (2006) under microwave conditions using a functional ionic liquid as a soluble support. 

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