Thermoresponsive materials graft copolymers with

Thermoresponsive control over the display of RGD peptides has been demonstrated by Okano and co-workers (Ebara et al., 2004). A temperature-sensitive copolymer, poly(A-isopropylacrylamide-co-2-carboxyisopropylacrylamide), is grafted on a surface and then decorated with RGD by attachment of the peptide to the carboxylic acid functionalities of the polymer. Cell adhesion is promoted at temperatures above the LCST but reduced below the LCST. This is explained with a modulation of the availability of the peptide at the material surface above the LCST, the polymer is collapsed and the peptide is available at the surface, whereas below the LCST, the polymer becomes soluble and the expanding polymer chains prevent access to the peptide (Figure 3.7(c)). 

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